Where is intrinsic factor

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Intrinsic factor is a natural substance normally found in the stomach. You need this substance to absorb vitamin B12 from foods. A lack of intrinsic factor leads to pernicious anemia and vitamin B12 deficiency, which can cause anemia and brain and nervous system neurological problems.

Babies that are born without intrinsic factor cannot properly absorb vitamin B12 starting around age 6 months. Children who have the juvenile type of lack of intrinsic factor tend to show signs and symptoms after age Older adults get pernicious anemia, which is caused by a lack of intrinsic factor production. This is usually due to an autoimmune disease that causes the stomach lining to waste away atrophy. The stomach lining is where intrinsic factor is usually made.

Antony AC. Megaloblastic anemias. Hematology: Basic Principles and Practice. Philadelphia, Pa: Churchill Livingstone; chap Swelling Spinal fractures. Dietary vitamin B 12 is released from ingested proteins in the stomach through the action of pepsin and acid. It is rapidly bound by one of two vitamin B 12 -binding proteins that are present in gastric juice; at acid pH, these binding proteins have a greater affinity for the vitamin than does intrinsic factor.

In the small intestine, pancreatic proteases digest the binding proteins, releasing vitamin B 12 which then becomes bound to intrinsic factor. Finally, there are receptors for intrinsic factor on the ileal mucosa which bind the complex, allowing vitamin B 12 to be absorbed into portal blood.

In all mammals, vitamin B 12 is necessary for maturation of erythrocytes, and a deficiency of this vitamin leads to development of anemia.