Where is pepsinogen converted to pepsin

To reiterate, the figure above illustrates that the neck cells of the gastric pits secrete mucus to protect the mucosa of the stomach from essentially digesting itself. Gastrin from G cells stimulates the parietal and chief cells to secrete hydrochloric acid and enzymes, respectively. Hydrochloric acid in the stomach denatures salivary amylase and other proteins by breaking down the structure and, thus, the function of it.

Hydrochloric acid also converts pepsinogen to the active enzyme pepsin. Pepsin is a protease, meaning that it cleaves bonds in proteins. It breaks down the proteins in food into individual peptides shorter segments of amino acids. The other enzyme that is active in the stomach is gastric lipase. This enzyme preferentially cleaves the sn-3 position of triglycerides to produce 1,2-diglyceride and a free fatty acid, as shown below 4.

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Show Summary Details Overview pepsinogen. Reference entries pepsinogen in A Dictionary of Biology 6 Length: 38 words. All rights reserved. Sign in to annotate. Delete Cancel Save.